Q1: What does MU-ACUC stand for?

MU-ACUC stands for Mansoura University Animal Care and Use Committee.

 Q2: I am applying for MU-ACUC approval for the first time. What forms do I need to fill out?

You will need to fill out a Consent Form applicable to the type of work you are doing (Master's, PhD/MD., or independent research), and a Study Proposal Form, as well as any supporting documentation you will be asked for finish your research.

 Q3: Do field studies or behavioral research require MU-ACUC approval?

Yes, MU-ACUC permission is required for any University activity that involves the use of vertebrate animals.

 Q4: What kind of animal-directed activities are reviewed and approved by the MU-ACUC?

An application must be submitted to the MU-ACUC committee for assessment and approval if vertebrate animals are utilized within the Mansoura university or within associated institutes.

 Q5: I would like to breed animals for scientific research. Is there a need for MU-ACUC approval?

Breeding stock is used as part of the institution's animal care and usage programme, and it directly supports research. As a result, protocols involving animals for such reasons must be approved by the MU-ACUC.

 Q6: Why is it required to obtain MU-ACUC certification before using animals?

The MU-ACUC's mission is to guarantee that the University adheres to the highest ethical standards in animal usage and complies with local animal care and use regulations.

 Q7: What is reviewed and approved by the MU-ACUC?

All study involving live animals, animal products, tissue, or genetic material, as well as any modifications to previously approved studies, such as the inclusion of new staff or changes to the work methodology.

 Q8: How long does it take for a protocol to be reviewed?

If no amendments are needed to the protocol, the average time from first submission to approval is 3 weeks.

 Q9: What factors does the MU-ACUC take into account while considering a research project?

Any aspect of the project that causes or has the potential to cause suffering, pain, or injury to the animals is of relevance. Harm can take many forms, including but not limited to pain, injury, death, and mental anguish. If animals are likely to be injured, documentation is required to show that other methods were considered but were not acceptable, why, that actions were taken to limit the harm, and that the scientific usefulness of the study outweighs the risk to the animals.

• A reason for employing animals is one of the other aspects that is taken into account.
• The protocol's goals are applicable.
• The suitability of the chosen species and the number of animals required.
• Measures of biosafety and infection control- if apply. 
• Euthanasia methods- if needed.
• Quality of all material and chemicals used. 

Q10: What are the chances that the MU-ACUC will reject my research proposal?

The MU-ACUC could reject a proposal if it does not satisfy the required criteria.

However, when a proposal is denied, the reviewers frequently propose ways to improve it. And, if the applicant and the MU-ACUC work together, a settlement and permission may typically be reached.

Q11: Can I purchase, collect, and transfer animals before I get an approval from MU-ACUC?

• No.
• The process of purchase, collection, and transfer of animals for research purposes can start only after the MU-ACUC acceptance is granted.

Q12: Why is the scientific value of my research being questioned by the MU-ACUC?

The MU-ACUC requires that the use of animals accomplishes the desired outcome. The MU-ACUC is concerned with the use of animals in your research, not the research itself. The MU-ACUC is concerned with ensuring that animal research adheres to the three R's (reduction, replacement, and refinement).

Q13: Do I have to fill an amendment request every time I want to make a modification to my proposal?

Any alteration to an animal-related project requires extra evaluation by the MU-ACUC, and the project cannot begin until the MU-ACUC has given its permission. The followings are examples of changes that may be made:

• Personnel additions and deletions.
• Changes in species and/or strain of the animal.
• An increase in the number of animals.
• Including or removing procedures.
• Changing or adding chemicals, anaesthetics, or other substances.
• Euthanasia method. 

Q14: What should I do if I need further information on how to care for and treat research animals properly?

• Call the Animal Facility Manager.
• Call the MU-ACUC Chairman.
• Call the MU-ACUC member who represents your faculty.

Q15: I received unofficial confirmation that my application was approved. When will I be able to begin my project?

Once you have got a written consent from the MU-ACUC, you can start your protocol.

Q16: What is meant by a transgenic animal?

Any animal that has had, or will have, a man-made alteration (induced mutation) to its genetic code is referred to as a transgenic animal. Typically, these animals are created to investigate the over-expression or under-expression of a given gene. Animals with spontaneous or spontaneously (non-research based) occurring mutations are often excluded from transgenic studies. An MU-ACUC permission is required if your research involves transgenic animals.

Q17: Who should be the Principal Investigator on an MU-ACUC application?

Principal investigators for research activities are limited to full-time staff members (in duty).

Q18: Who should submit an application to, and correspond with the MU-ACUC?

The principal investigator, who is usually listed as first name on the research protocol, is the entitled person to submit an application and to correspond with the MU-ACUC. He is also the person whom the approval letter of the protocol will be directed to him from the MU-ACUC.